Contraceptive pill-induced porphyria cutanea tarda presenting with onycholysis of the finger nails.

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Contraceptive pill-induced porphyria cutanea tarda presenting with onycholysis of the finger nails.

A case of porphyria cutanea tarda induced by oral contraceptive pill therapy is reported, and its unusual presenting sign of onycholysis of the finger nails is noted. Reference is made to the rarity of nail changes in porphyria and the regression of the onycholysis in the patient following therapy is outlined.

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Porphyria cutanea tarda is a metabolic disorder in the haem biosynthetic pathway. It includes a heterogeneous group of conditions, which may be inherited or, more commonly, acquired. Although porphyria cutanea tarda presents with cutaneous lesions only, it is often associated with systemic disease. A 64-year-old Chinese patient, who developed sporadic porphyria cutanea tarda 1 year after the di...

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Clinical spectrum of porphyria cutanea tarda.

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Porphyrias are an uncommon, heterogeneous group of metabolic diseases caused by inherited or acquired deficiency of specific enzymes in the heme biosynthetic pathway resulting in an excess of porphyrins (red-brown pigments) and their precursors. Accumulation of heme precursors, such as porphyrinogens that are spontaneously oxidized to porphyrins, is responsible for various clinical features. Po...

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ژورنال

عنوان ژورنال: Postgraduate Medical Journal

سال: 1976

ISSN: 0032-5473

DOI: 10.1136/pgmj.52.610.535